Alka-Seltzer is an antacid and pain reliever. Its effervescent "fizzing" tablets release active ingredients when dissolved in water. Developed by head chemist Maurice Treneer, it was first marketed by Dr. Franklin L. Miles of Miles Laboratories fame in Elkhart, Indiana in 1884. Print advertising was used immediately, and by 1932 the radio show Alka-Seltzer Comedy Star of Hollywood began, along with many more. The radio sponsorships continued into the 1950s, with the Alka-Seltzer Time show airing from 1949 to 1957. Miles Laboratories was purchased by Bayer in 1979.
Alka-Seltzer's "Speedy" character was introduced in 1951. His body was made of one Alka-Seltzer tablet, while he wore another as a hat. It was conceived by Chicago's Wade Advertising Agency (1909-1966) and designed by illustrator Wally Wood. Originally named Sparky, the name was changed to Speedy to align with that year's promotional theme, "Speedy Relief". Speedy appeared in over 200 television commercials between 1954 and 1964. Actor Buster Keaton (above) assumed various occupations for a series of commercials with the mascot. The ads through the 1970s were among the most popular of the 20th century in the United States. Adding to the success was Speedy's jingle, "Plop, plop, fizz, fizz, oh what a relief it is" with an adult providing a child-like cartoon voice. Speedy was resurrected a few times over the coming decades. In 2008 Alka-Seltzer began a series of new commercials featuring the character using modern computer graphics.